HCA Data Portal

Cell Annotation Metadata

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Annotation

FieldDescription
Cell Full Name
Required

string

Description
Allowed Values
Example
rod bipolar
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Cell Ontology Exists
Required

boolean

Description
Allowed Values
Example
True
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Cell Ontology Term ID
Required

string

Description
Allowed Values
Example
CL:0000751
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Cell Ontology Term
Required

string

Description
Allowed Values
Example
rod bipolar cell
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Rationale
Required

string

Description
Allowed Values
Example
This cell was annotated with [blank] given the canonical markers in the field [X], [Y], [Z]. We noticed [X] and [Y] running differential expression.
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Rationale DOIs
Recommended

string (multivalued)

Description
Allowed Values
Example
10.1038/s41587-022-01468-y, 10.1038/s41556-021-00787-7, 10.1038/s41586-021-03465-8
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Marker Gene Evidence
Required

string (multivalued)

Description
Allowed Values
Example
TP53, KRAS, BRCA1
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Canonical Marker Genes
Required

string (multivalued)

Description
Allowed Values
Example
GATA3, CD3D, CD3E
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Synonyms
Required

string (multivalued)

Description
Allowed Values
Example
neuroglial cell, glial cell, neuroglia
amacrine cell
FMB cell
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Category Full Name
Required

string

Description
Allowed Values
Example
ON-bipolar cell
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Category Cell Ontology Exists
Required

boolean

Description
Allowed Values
Example
True
Source
Cell Annotation Schema
BioNetworks
AnnData Location
Show more
Category Cell Ontology Term ID
Required

string

Description
Allowed Values
Example
CL:0000749
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Category Cell Ontology Term
Required

string

Description
Allowed Values
Example
ON-bipolar cell
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Cell Ontology Assessment
Recommended

string

Description
Allowed Values
Example
Amacrine cell should have four child terms: glycinergic, GABAergic, GABAergic Glycinergic amacrine cells and non-GABAergic non-glycinergic amacrine cells, which then contain their corresponding child terms
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Annotation Set

FieldDescription
Annotation Set Metadata
Required

python dictionary

Description
Example
'{{cellannotation_set}--metadata:{'annotation_method':'algorithmic'...}}'
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Cell Annotation Set Name
Required

string

Description
Allowed Values
Example
HBC2
rod bipolar
Source
Cell Annotation Schema
BioNetworks
AnnData Location
Show more
Description
Required

string

Description
Allowed Values
Example
Cell annotations based on resolution broad clustering using the Leiden algorithm.
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Algorithm Name
Required

string

Description
Allowed Values
Example
scArches
NA
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Algorithm Version
Required

string

Description
Allowed Values
Example
0.5.9
NA
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Algorithm Repository URL
Required

string

Description
Allowed Values
Example
https://github.com/theislab/scarches
NA
Source
Cell Annotation Schema
BioNetworks
AnnData Location
Show more
Annotation Method
Required

string

Description
Allowed Values
Example
algorithmic
manual
both
Source
Cell Annotation Schema
BioNetworks
AnnData Location
Show more
Reference Location
Recommended

string

Description
Allowed Values
Example
https://figshare.com/projects/Tabula_Muris_Senis/64982
NA
Source
Cell Annotation Schema
BioNetworks
AnnData Location
Show more
Reference Description
Recommended

string

Description
Allowed Values
Example
Tabula Muris Senis: a single cell transcriptomic atlas across the life span of Mus musculus which includes data from 18 tissues and organs.
NA
Source
Cell Annotation Schema
BioNetworks
AnnData Location
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Cluster

FieldDescription
Clustering
Recommended

string (multivalued)

Description
Allowed Values
Example
cluster_leiden
cluster_leiden_broad
louvain
leiden
Source
Cell Annotation Schema
BioNetworks
AnnData Location
Show more
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