Human Cortical Cell Atlas v1.0
A highly detailed atlas of cellular diversity and variation across the neocortexAtlas Description
The cerebral cortex is essential for many of our behaviors and higher-order cognitive functions and exhibits striking cytoarchitectural, cellular, molecular, and functional variation. The Human Cortical Cell Atlas v1.0 is based on a highly detailed analysis of 8 cortical regions spanning the range of functional, structural, and topographic variation in the human neocortex. These include regions that include primary (motor, M1; somatosensory, S1; auditory, A1; visual, V1) and association areas (dorsolateral prefrontal cortex, DFC, specifically Brodmann area 9 in the superior frontal gyrus; anterior cingulate cortex, ACC; middle temporal gyrus, MTG; angular gyrus, AnG), span the rostral to caudal extent of the cortical sheet, and represent major variations in cortical cytoarchitecture. Single nucleus RNA-seq (both SMART-seqv.4 and 10X Chromium v.3) was performed on over one million isolated nuclei.
The Human Cortical Cell Atlas v1.0 is presented for visualization and data mining through the Chan Zuckerberg Initiative’s CELLxGENE application, with the following biologically meaningful partitions:
- Supercluster-specific groupings
- Cortical region-specific groupings
| Atlas Name | Tissue | Disease | Cells | Explore | Download |
|---|---|---|---|---|---|
Supercluster: IT-projecting excitatory neurons | 8 tissues | normal | 638.9k | ||
Dissection: Primary visual cortex(V1) | primary visual cortex | normal | 241.1k | ||
Supercluster: MGE-derived interneurons | 8 tissues | normal | 185.5k | ||
Dissection: Primary somatosensory cortex (S1) | primary somatosensory cortex | normal | 153.2k | ||
Dissection: Middle temporal gyrus (MTG) | middle temporal gyrus | normal | 148.4k | ||
Dissection: Primary auditory cortex(A1) | primary auditory cortex | normal | 139.1k | ||
Dissection: Anterior cingulate cortex (ACC) | anterior cingulate cortex | normal | 135.5k | ||
Supercluster: CGE-derived interneurons | 8 tissues | normal | 129.5k | ||
Dissection: Primary motor cortex (M1) | primary motor cortex | normal | 114.6k | ||
Dissection: Dorsolateral prefrontal cortex (DFC) | dorsolateral prefrontal cortex | normal | 113.3k | ||
Dissection: Angular gyrus (AnG) | angular gyrus | normal | 110.8k | ||
Supercluster: Non-neuronal cells | 8 tissues | normal | 108.9k | ||
Supercluster: Deep layer (non-IT) excitatory neurons | 8 tissues | normal | 93.0k | ||
Human Multiple Cortical Areas SMART-seq | 6 tissues | normal | 49.4k |
