HCA Data Portal
Kidney Network

Kidney Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A Partial Picture of the Single-Cell Transcriptomics of Human IgA Nephropathy

Homo sapiens

GEXSCOPE technology

kidney

normal

IgA glomerulonephritis

20,570

A human cell atlas of fetal gene expression.

Homo sapiens

sci-RNA-seq3

14 anatomical entities
normal

4,062,965

Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects
3 species
12 library construction methods
4 anatomical entities
normal

50,556

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Homo sapiens

4 library construction methods
8 anatomical entities
5 diseases

106,792

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

Homo sapiens

2 library construction methods

kidney

normal

123,408

Construction of A Human Cell Landscape by Single-cell mRNA-seq

Homo sapiens

Microwell-Seq

37 anatomical entities
normal
19 diseases

702,968

Decoding human fetal liver haematopoiesis

Homo sapiens

2 library construction methods
4 anatomical entities
normal

223,112

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Homo sapiens

2 library construction methods

kidney

2 diseases

150,000

Detection of infiltrating fibroblasts by single-cell transcriptomics in human kidney allografts

Homo sapiens

10x 3' v2

kidney

normal
6 diseases

7,217

Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells

Homo sapiens

2 library construction methods
3 anatomical entities

Unspecified

Unspecified

Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing

Homo sapiens

STRT-seq

kidney

normal

3,000

HCA seed network precise tumor-nephrectomy samples

Homo sapiens

10x 3' v3

kidney

kidney cancer

345,521

Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing To Define Immune Cell Chimerism in the Rejecting Kidney Transplant

Homo sapiens

2 library construction methods

kidney

4 diseases

81,139

Healthy human kidney cell type single cell RNA-seq data

Homo sapiens

10x 3' v3

kidney

Unspecified

156,624

Intrarenal Single-Cell Sequencing of Hepatitis B Virus Associated Membranous Nephropathy.

Homo sapiens

GEXSCOPE technology

kidney

2 diseases

15,614

Joint profiling of chromatin accessibility and gene expression in thousands of single cells
2 species
2 library construction methods
4 anatomical entities
normal

lung adenocarcinoma

16,120

Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer.

Homo sapiens

2 library construction methods
3 anatomical entities
2 diseases

270,000

Mapping the developing human immune system across organs
2 species
5 library construction methods
10 anatomical entities
normal

922,332

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

Homo sapiens

2 library construction methods
2 anatomical entities

renal cell carcinoma (disease)

37,055

Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progression

Homo sapiens

3 library construction methods

kidney

19 diseases

90,793

Pathogen-induced tissue-resident memory T <sub>H</sub> 17 (T <sub>RM</sub> 17) cells amplify autoimmune kidney disease

Homo sapiens

CITE-seq

2 anatomical entities
2 diseases

32,593

Single Cell RNA-Seq profiling human embryonic kidney cortex cells

Homo sapiens

10X 3' V2 sequencing

kidney

normal

4,000

Single Cell RNA-Seq profiling of human embryonic kidney outer and inner cortical cells and kidney organoid cells

Homo sapiens

10x 3' v2

2 anatomical entities
normal

Unspecified

Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis

Homo sapiens

Fluidigm C1-based library preparation

3 anatomical entities
normal

systemic lupus erythematosus

899

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney

Homo sapiens

2 library construction methods

kidney

13 diseases

98,550

Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker.

Homo sapiens

2 library construction methods

kidney

normal

kidney neoplasm

22,268

Single-Cell RNA Sequencing in Multiple Pathologic Types of Renal Cell Carcinoma Revealed Novel Potential Tumor-Specific Markers.

Homo sapiens

10x 3' v3

kidney

3 diseases

30,263

Single-Cell RNA-Seq Analysis of cells from human urine

Homo sapiens

10x 3' V3 sequencing

renal system

normal

Unspecified

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell

Homo sapiens

3 library construction methods
3 anatomical entities
normal
3 diseases

21,964

Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy

Homo sapiens

STRT-seq

2 anatomical entities
normal
4 diseases

3,620

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response

Homo sapiens

inDrop

kidney

2 diseases

4,000

Single-cell RNA sequencing of human kidney

Homo sapiens

10x 3' v2

kidney

2 diseases

23,366

Single-cell RNA sequencing of urinary cells reveals distinct cellular diversity in COVID-19-associated AKI

Homo sapiens

10x 3' V3

urine

2 diseases

30,076

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response

Homo sapiens

10x 3' v2

kidney

2 diseases

29,041

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

Homo sapiens

10x 3' v3

kidney

normal

27,677

Single-cell protein activity analysis identifies recurrence-associated renal tumor macrophages.

Homo sapiens

10x 3' v2

kidney

clear cell renal carcinoma

200,000

Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.

Homo sapiens

2 library construction methods
3 anatomical entities
2 diseases

167,283

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

Homo sapiens

10x 3' v2

2 anatomical entities
normal
4 diseases

72,501

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression

Homo sapiens

3 library construction methods

kidney

normal
3 diseases

453,782

Spatio-temporal immune zonation of the human kidney

Homo sapiens

10x 3' v2

kidney

normal
4 diseases

28,785

Tabula Muris: Transcriptomic characterization of 20 organs and tissues from Mus musculus at single cell resolution

Mus musculus

Smart-seq2

18 anatomical entities
normal

100,605

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Homo sapiens

3 library construction methods
24 anatomical entities
normal
10 diseases

481,120

The immune cell landscape in kidneys of patients with lupus nephritis.

Homo sapiens

2 library construction methods
2 anatomical entities
normal

lupus nephritis

9,200

The single-cell transcriptomic landscape of early human diabetic nephropathy

Homo sapiens

10x 5' v2

kidney

24 diseases

30,000

Ureter single-cell and spatial mapping reveal cell types, architecture, and signaling networks

Homo sapiens

2 library construction methods

ureter

normal

30,942