HCA Data Portal
Oral and Craniofacial Networks

Oral and Craniofacial Networks

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A Protocol for Revealing Oral Neutrophil Heterogeneity by Single-Cell Immune Profiling in Human Saliva

Homo sapiens

Smart-seq2

oral cavity

normal

1,145

A Single-Cell Atlas of the Human Healthy Airways

Homo sapiens

10x 3' v2

3 anatomical entities
normal

77,969

A cellular census of human lungs identifies novel cell states in health and in asthma

Homo sapiens

2 library construction methods
2 anatomical entities
normal

chronic obstructive pulmonary disease

47,291

A single-cell atlas of human teeth

Homo sapiens

10x 3' v2 sequencing

molar tooth

normal

100,000

Allergic inflammatory memory in human respiratory epithelial progenitor cells

Homo sapiens

Seq-Well

nose

normal
2 diseases

36,740

An Atlas of Cells in the Human Tonsil

Homo sapiens

7 library construction methods

palatine tonsil

5 diseases

357,000

Comprehensive cell atlas of the first-trimester developing human brain

Homo sapiens

2 library construction methods
2 anatomical entities
normal

1,665,937

Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease

Homo sapiens

10x 3' v3

mouth

normal

chronic periodontitis

Unspecified

Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation
2 species

10x 3' v2

mouth

normal

6,653

High-Resolution Transcriptomic Landscape of the Human Submandibular Gland.

Homo sapiens

10x 3' v2

mouth

normal

15,695

Human SARS-CoV-2 challenge resolves local and systemic response dynamics

Homo sapiens

2 library construction methods
2 anatomical entities

COVID-19

606,074

Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity

Homo sapiens

10x 3' V3 sequencing

mouth mucosa

normal

periodontal disease

88,000

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

Homo sapiens

10X 3' v2 sequencing

2 anatomical entities
normal
11 diseases

126,000

Integrated single-cell transcriptomics and epigenomics reveals strong germinal center–associated etiology of autoimmune risk loci

Homo sapiens

2 library construction methods

tonsil

normal

Unspecified

Lifespan charactarization of the nasal mucosa

Homo sapiens

10x 3' v3

nose

normal
5 diseases

Unspecified

Local and systemic responses to SARS-CoV-2 infection in children and adults

Homo sapiens

2 library construction methods
3 anatomical entities
normal
2 diseases

659,217

RNA-Seq from human innate lymphoid cells (ILCs) transitional populations.

Homo sapiens

cDNA library construction

tonsil

tonsillitis

15,000

SARS-CoV-2 infection of the oral cavity and saliva.

Homo sapiens

10X 3' v3

mouth

2 diseases

13,824

SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues.
2 species
4 library construction methods
4 anatomical entities
normal

33,844

Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease.

Homo sapiens

10x 3' v3

saliva-secreting gland

normal

21,402

Single cell RNA-sequencing of human tonsil Innate lymphoid cells (ILCs)

Homo sapiens

Smart-seq2

tonsil

obstructive sleep apnea syndrome

648

Single-Cell Transcriptomic Profiling of Human Dental Pulp in Sound and Carious Teeth: A Pilot Study

Homo sapiens

10x 3' v2

2 anatomical entities
normal
2 diseases

6,810

Single-cell RNA sequencing of human nasal swab from healthy donors

Homo sapiens

barcoded plate-based single cell RNA-seq

nose

normal

Unspecified

Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

Homo sapiens

3 library construction methods

palatine tonsil

2 diseases

52,541

Single-cell sequencing unveils the heterogeneity of nonimmune cells in chronic apical periodontitis

Homo sapiens

10x 3' v2

molar tooth

chronic apical periodontitis

26,737

Single-cell transcriptomic analysis of gingivo-buccal oral cancer reveals two dominant cellular programs

Homo sapiens

10x 3' v3

mouth

2 diseases

52,393

Tabula Muris: Transcriptomic characterization of 20 organs and tissues from Mus musculus at single cell resolution

Mus musculus

Smart-seq2

18 anatomical entities
normal

100,605

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Homo sapiens

3 library construction methods
24 anatomical entities
normal
10 diseases

481,120

The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma

Homo sapiens

5 library construction methods
12 anatomical entities
2 diseases

764,251