The integrated Human Lung Cell Atlas (HLCA) v1.0

The datasets below are ingested in the HCA Data Portal and used in the creation of the related integrated atlas. Additional datasets may have been used in the creation of the atlas. See the atlas publication for the full list of source datasets for the atlas.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A cellular census of human lungs identifies novel cell states in health and in asthma

Homo sapiens

2 library construction methods
2 anatomical entities
normal

chronic obstructive pulmonary disease

47,291

A molecular cell atlas of the human lung from single-cell RNA sequencing
2 species
2 library construction methods
2 anatomical entities
normal
3 diseases

75,000

A Single-Cell Atlas of the Human Healthy Airways

Homo sapiens

10x 3' v2

3 anatomical entities
normal

77,969

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Homo sapiens

6 library construction methods

lung

normal

type 2 diabetes mellitus

193,108

Airspace Macrophages and Monocytes Exist in Transcriptionally Distinct Subsets in Healthy Adults

Homo sapiens

10x 3' v3

lung

normal

49,384

Allergic inflammatory memory in human respiratory epithelial progenitor cells

Homo sapiens

Seq-Well

nose

normal
2 diseases

36,740

Barbry_unpubl

--

10X 3' v3

--

IPF

100,211

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia.

Homo sapiens

10x 5' v2

lung

3 diseases

77,146

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis
2 species

10x 3' v2

lung

normal
3 diseases

109,269

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.

Homo sapiens

4 library construction methods
8 anatomical entities
5 diseases

106,792

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Homo sapiens

10x 5' v2

lung

2 diseases

65,166

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

Homo sapiens

3 library construction methods

trachea

normal
4 diseases

42,224

Duong_lungMAP_unpubl

--

10X 3' v3

--

normal

53,904

Expansion of profibrotic monocyte-derived alveolar macrophages in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

--

2 library construction methods

--

normal

45,557

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

Homo sapiens

2 library construction methods

lung

Unspecified

21,700

Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers

Homo sapiens

Drop-seq

lung

normal
2 diseases

41,888

Local and systemic responses to SARS-CoV-2 infection in children and adults

Homo sapiens

2 library construction methods
3 anatomical entities
normal
2 diseases

659,217

Lung transplantation for patients with severe COVID-19

Homo sapiens

10x 3' v3

lung

normal
9 diseases

91,980

Phenotype molding of stromal cells in the lung tumor microenvironment

Homo sapiens

2 library construction methods

lung

5 diseases

92,948

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

Homo sapiens

2 library construction methods

lung

normal

interstitial lung disease 2

47,771

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

Homo sapiens

2 library construction methods
5 anatomical entities
2 diseases

49,253

SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

Homo sapiens

10x 3' v2

lung

normal

lung adenocarcinoma

57,299

Schiller_2021

--

10X 3' v3

--

Cancer (non-cancerous tissue used for samples)

35,984

Schultze_unpubl

--

Seq-Well

--

Cancer (non-cancerous tissue used for samples)

8,016

scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation

Homo sapiens

3 library construction methods
3 anatomical entities
normal

199,845

Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease

Homo sapiens

4 library construction methods

lung

normal
4 diseases

56,196

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Homo sapiens

4 library construction methods

lung

normal
4 diseases

37,820

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

Homo sapiens

2 library construction methods

lung

normal

137,480

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Homo sapiens

2 library construction methods

lung

normal
5 diseases

114,396

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

Homo sapiens

10x 3' v2

lung

normal
2 diseases

312,928

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell

Homo sapiens

3 library construction methods
3 anatomical entities
normal
3 diseases

21,964

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
2 species

10x 3' v2

lung

normal
5 diseases

76,070

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

Homo sapiens

10x 3' v2

4 anatomical entities
normal

hypertension

50,000

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

Homo sapiens

3 library construction methods

lung

normal

cystic fibrosis

Unspecified

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