HCA Data Portal
Eye Network

Eye Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project TitleSpeciesMethodAnatomical EntityDisease (Donor)Cell Count Est.
A human cell atlas of fetal gene expression.

Homo sapiens

sci-RNA-seq3

14 anatomical entities
normal

4,062,965

A multi-omics atlas of the human retina at single-cell resolution

Homo sapiens

2 library construction methods

eye

Unspecified

536,508

A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells.

Homo sapiens

2 library construction methods

eye

normal
2 diseases

21,343

A single-cell transcriptome atlas of the adult human retina

Homo sapiens

10x 3' v2

eye

normal

cataract (disease)

44,000

A single-cell transcriptomic atlas of the human ciliary body

Homo sapiens

BD Rhapsody Whole Transcriptome Analysis

eye

normal

lung cancer

14,563

Cell Atlas of The Human Fovea and Peripheral Retina

Homo sapiens

10x technology

eye

5 diseases

84,982

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

Homo sapiens

2 library construction methods
2 anatomical entities

Unspecified

285,411

Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types

Homo sapiens

10x 3' v3

eye

metastatic melanoma

253,823

Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids

Homo sapiens

2 library construction methods
2 anatomical entities
normal

510,000

Construction of A Human Cell Landscape by Single-cell mRNA-seq

Homo sapiens

Microwell-Seq

37 anatomical entities
normal
19 diseases

702,968

Dissecting transcriptional and chromatin accessibility heterogeneity of proliferating cone precursors in human retinoblastoma tumours by single cell sequencing

Homo sapiens

10x 3' v3

eye

normal

retinoblastoma

8,086

Evolution of neuronal cell classes and types in the vertebrate retina

Homo sapiens

10x 3' v3

eye

normal

174,563

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.

Mus musculus

Drop-seq

eye

normal

44,808

Human photoreceptor cells from different macular subregions have distinct transcriptional profiles

Homo sapiens

10x 3' v1

retina

normal

lung cancer

34,493

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration

Homo sapiens

10x 3' v3

eye

normal

100,055

Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing

Homo sapiens

10x 3' v3

retina

normal

glaucoma (disease)

8,217

Single Cell Multiome Atlas of the Human Fetal Retina

Homo sapiens

2 library construction methods

eye

Unspecified

592,316

Single cell atlas of the human retina

Homo sapiens

2 library construction methods

eye

Unspecified

Unspecified

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.
2 species

10X 3' v2

eye

normal

Choroidal neovascularization

30,007

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.

Homo sapiens

10x 3' v2

2 anatomical entities
normal

289,000

Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases

Homo sapiens

10x multiome

eye

normal

dementia

51,645

Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation

Homo sapiens

2 library construction methods

eye

Unspecified

Unspecified

Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration

Homo sapiens

2 library construction methods

eye

normal

23,339

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

Homo sapiens

10x v3 sequencing

eye

normal
2 diseases

18,560

Single-cell transcriptomics uncovers human corneal limbal stem cells and their differentiation trajectory.

Homo sapiens

10X 3' v2 sequencing

eye

normal

18,000

Spatial transcriptomic profiling of human retinoblastoma

Homo sapiens

Visium Spatial Gene Expression

eye

3 diseases

6,743

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

Homo sapiens

3 library construction methods
24 anatomical entities
normal
10 diseases

481,120

Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye

Homo sapiens

10x 3' v3

2 anatomical entities
3 diseases

139,978