Eye Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project Title	Species	Method	Anatomical Entity	Disease (Donor)	Cell Count Est.
A human cell atlas of fetal gene expression.	Homo sapiens	sci-RNA-seq3	14 anatomical entities	normal	4,062,965
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells.	Homo sapiens	2 library construction methods	eye	normal 2 diseases	21,343
A single-cell transcriptome atlas of the adult human retina	Homo sapiens	10x 3' v2	eye	normal cataract (disease)	44,000
A single-cell transcriptomic atlas of the human ciliary body	Homo sapiens	BD Rhapsody Whole Transcriptome Analysis	eye	normal lung cancer	14,563
Cell Atlas of The Human Fovea and Peripheral Retina	Homo sapiens	10x technology	eye	5 diseases	84,982
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution	Homo sapiens	2 library construction methods	2 anatomical entities	Unspecified	285,411
Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types	Homo sapiens	10x 3' v3	3 anatomical entities	normal 5 diseases	Unspecified
Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids	Homo sapiens	2 library construction methods	2 anatomical entities	normal	510,000
Construction of A Human Cell Landscape by Single-cell mRNA-seq	Homo sapiens	Microwell-Seq	37 anatomical entities	normal 19 diseases	702,968
Dissecting transcriptional and chromatin accessibility heterogeneity of proliferating cone precursors in human retinoblastoma tumours by single cell sequencing	Homo sapiens	10x 3' v3	eye	normal retinoblastoma	8,086
Evolution of neuronal cell classes and types in the vertebrate retina	Homo sapiens	10x 3' v3	eye	normal	174,563
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.	Mus musculus	Drop-seq	eye	normal	44,808
Human photoreceptor cells from different macular subregions have distinct transcriptional profiles	Homo sapiens	10x 3' v1	retina	normal lung cancer	34,493
Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration	Homo sapiens	10x 3' v3	eye	normal	100,055
Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing	Homo sapiens	10x 3' v3	retina	normal glaucoma (disease)	8,217
Single Cell Multiome Atlas of the Human Fetal Retina	Homo sapiens	2 library construction methods	eye	Unspecified	Unspecified
Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.	2 species	10X 3' v2	eye	normal Choroidal neovascularization	30,007
Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures	Homo sapiens	3 library construction methods	2 anatomical entities	normal	77,394
Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.	Homo sapiens	10x 3' v2	2 anatomical entities	normal	289,000
Single-cell multiome of the human retina and deep learning nominate causal variants in complex eye diseases	Homo sapiens	10x multiome	eye	normal dementia	51,645
Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration	Homo sapiens	2 library construction methods	eye	normal	23,339
Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration	Homo sapiens	10x v3 sequencing	eye	normal 2 diseases	18,560
Single-cell transcriptomics uncovers human corneal limbal stem cells and their differentiation trajectory.	Homo sapiens	10X 3' v2 sequencing	eye	normal	18,000
Spatial transcriptomic profiling of human retinoblastoma	Homo sapiens	Visium Spatial Gene Expression	eye	3 diseases	6,743
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans	Homo sapiens	3 library construction methods	24 anatomical entities	normal 10 diseases	481,120
Transcriptomic analysis of the ocular posterior segment completes a cell atlas of the human eye	Homo sapiens	10x 3' v3	2 anatomical entities	3 diseases	Unspecified