Development Network

The HCA datasets below focus on the network's tissues and are potential source datasets for integrated atlases.

Project Title	Species	Method	Anatomical Entity	Disease (Donor)	Cell Count Est.
A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization	Homo sapiens	Smart-like	embryo	normal	1,014
A human embryonic limb cell atlas resolved in space and time	2 species	4 library construction methods	2 anatomical entities	normal	125,955
A single-cell molecular map of mouse gastrulation and early organogenesis	Mus musculus	10X 3' v1 sequencing	embryo	Unspecified	339,089
A single-cell transcriptome atlas of human early embryogenesis	Homo sapiens	10x 3' v2	embryo	normal	103,264
Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects	3 species	12 library construction methods	4 anatomical entities	normal	50,556
Capturing human trophoblast development with naive pluripotent stem cells in vitro	Homo sapiens	10X 3' v3	embryo	normal	14,164
Construction of A Human Cell Landscape by Single-cell mRNA-seq	Homo sapiens	Microwell-Seq	37 anatomical entities	normal 19 diseases	702,968
Decoding Human Megakaryocyte Development	Homo sapiens	2 library construction methods	3 anatomical entities	normal	18,698
Dissecting the clonal nature of allelic expression in somatic cells by single-cell RNA-seq	2 species	Smart-seq2	5 anatomical entities	normal	1,318
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.	Homo sapiens	Fluidigm C1-based library preparation	3 anatomical entities	normal	734
Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution	Homo sapiens	3 library construction methods	2 anatomical entities	normal 6 diseases	154,748
Joint profiling of chromatin accessibility and gene expression in thousands of single cells	2 species	2 library construction methods	4 anatomical entities	normal lung adenocarcinoma	16,120
Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells.	Homo sapiens	10x 3' v2	embryo	normal	4,000
Kidney organoid reproducibility across multiple human iPSC lines and diminished off target cells after transplantation revealed by single cell transcriptomics	Homo sapiens	10x 3' v2	2 anatomical entities	normal	450,118
Molecular transitions in early progenitors during human cord blood hematopoiesis	Homo sapiens	Drop-Seq	umbilical cord	normal	20,000
Organoid single-cell genomic atlas uncovers human-specific features of brain development	Homo sapiens	5 library construction methods	3 anatomical entities	normal	19,916
Single Cell RNA-Seq profiling of human embryonic kidney outer and inner cortical cells and kidney organoid cells	Homo sapiens	10x 3' v2	2 anatomical entities	normal	Unspecified
Single Cell RNA-Sequencing of Human Limb Skeletal Muscle across Development and Myogenic Culture from Pluripotent Stem Cells	Homo sapiens	Drop-seq	3 anatomical entities	normal	94,600
Single cell RNA-Seq of E18.5 developing mouse kidney and human kidney organoids	2 species	10x 3' v2	2 anatomical entities	normal	14,585
Single cell profiling of human induced dendritic cells generated by direct reprogramming of embryonic fibroblasts	Homo sapiens	10x 3' v2	embryo	normal	6,263
Single-cell RNA-seq analysis throughout a 125-day differentiation protocol that converted H1 human embryonic stem cells to a variety of ventrally-derived cell types.	Homo sapiens	Smart-seq2	embryo	normal	Unspecified
Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells	Homo sapiens	Smart-seq2	umbilical cord	normal	420
Single-nuclei profiling of aged skeletal muscle	Homo sapiens	10x 5' v1	hindlimb	normal	143,051
Spatiotemporal Analysis of Human Intestinal Development at Single Cell Resolution - scRNA-Seq	Homo sapiens	2 library construction methods	3 anatomical entities	normal 2 diseases	98,866
The emergent landscape of the mouse gut endoderm at single-cell resolution	Mus musculus	10x 3' v2	3 anatomical entities	normal	112,201
Tracing pluripotency of human early embryos and embryonic stem cells by single cell RNA-seq	Homo sapiens	Smart-seq2	2 anatomical entities	normal	124
Transcriptomes of 1,529 individual cells from 88 human preimplantation embryos	Homo sapiens	Smart-seq2	embryo	normal	1,500