RNA-Seq from human innate lymphoid cells (ILCs) transitional populations.
Updated November 10, 2022Innate lymphoid cells (ILCs) are tissue-resident lymphocytes subdivided into ILC1s, ILC2s and ILC3s based on core regulatory programs and signature cytokines secreted. ILCs exhibit functional plasticity. Using flow cytometry, mass cytometry and scRNAseq, here we found that ILC3s and ILC1s occupy opposite ends of a spectrum including discrete subsets in human tonsils. The human intestine also exhibited an ILC3–ILC1 transitional population. Overall design: ILCs were sorted from human tonsils and human intestine and analysed by scRNA-seq and bulk RNA-seq. The sc-RNAseq sequencing data is available upon reasonable request to the authors.
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Analysis Portals
NoneProject Label
InnateLymphoidCellsSpecies
Sample Type
Anatomical Entity
Organ Part
Selected Cell Types
Disease Status (Specimen)
Disease Status (Donor)
Development Stage
Library Construction Method
Nucleic Acid Source
Paired End
falseAnalysis Protocol
analysis_protocol_bulk_sequencingFile Format
Cell Count Estimate
15.0kDonor Count
3