Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk.
Updated March 10, 2023During development, distinct progenitors contribute to the nephrons versus the ureteric epithelium of the kidney. By performing single-cell RNA sequencing on iPSC-derived kidney organoids and primary fetal kidney tissue and by reanalysing the transcriptional distinction between distal nephron and ureteric epithelium in human fetal kidney, the authors show that while existing nephron-containing kidney organoids contain distal nephron epithelium and no ureteric epithelium, this distal nephron segment alone displays significant in vitro plasticity and can adopt a ureteric epithelial tip identity when isolated and cultured in defined conditions.
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Analysis Portals
NoneProject Label
KidneyOrganoidsPlasticitySpecies
Sample Type
Anatomical Entity
Organ Part
Selected Cell Types
Model Organ
Disease Status (Specimen)
Disease Status (Donor)
Development Stage
Library Construction Method
Nucleic Acid Source
Paired End
false, trueAnalysis Protocol
analysis_protocol_bulk_cells, analysis_protocol_single_cellsFile Format
Cell Count Estimate
10.0kDonor Count
1