HCA Data Explorer

Transcriptomic and clonal characterization of T cells in the human central nervous system.

Updated July 19, 2023

Tissues develop unique homeostatic immune states through specific recruitment of immune cells that are further shaped by the tissue environment. Single-cell RNA of healthy cerebrospinal fluid (CSF) and single-nucleus RNA sequencing of brain parenchyma was used to profile the T cell state in the human central nervous system (CNS).

David van DijkYale School of Medicinedavid.vandijk@yale.edu
David A HaflerYale School of Medicinedavid.hafler@yale.edu
Jenna L Pappalardo1
Le Zhang1
Maggie K Pecsok1
Kelly Perlman2
Chrysoula Zografou1
Khadir Raddassi1
Ahmad Abulaban1
Smita Krishnaswamy1
Jack Antel2
David van Dijk1
David A Hafler1
1Yale School of Medicine
2Montreal Neurologic Institute
Ami Day

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/d3a4ceac-4d66-4984-9704-2570c0647a56
None
INSDC Project Accessions:GEO Series Accessions:INSDC Study Accessions:

Downloaded and exported data is governed by the HCA Data Release Policy and licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). For more information please see our Data Use Agreement.

Analysis Portals

None

Project Label

TCellsHumanCentralNervousSystem

Species

Homo sapiens

Sample Type

specimens

Anatomical Entity

brain

Organ Part

2 organ parts

Selected Cell Types

Unspecified

Disease Status (Specimen)

normal

Disease Status (Donor)

3 disease statuses

Development Stage

human adult stage

Library Construction Method

10x 3' v3 sequencing

Nucleic Acid Source

single cell

Paired End

false

File Format

6 file formats

Cell Count Estimate

50.5k

Donor Count

3
bam6 file(s)fastq.gz135 file(s)loom7 file(s)tar1 file(s)xlsx1 file(s)zip1 file(s)