Single-cell RNA Sequencing of human microglia from post mortem Alzheimers Disease CNS tissue.
Updated June 24, 2022The transcriptomes of microglia were investigated at a single cell level in non-demented elderly and Alzheimers Disease donors using acute human post-mortem cortical brain samples.
Astrid M Alsema1
Qiong Jiang1
Laura Kracht1
Emma Gerrits1
Marissa L Dubbelaar1
Anneke Miedema1
Nieske Brouwer1
Elly M Hol2
Jinte Middeldorp2
Roland van Dijk2
Maya Woodbury3
Astrid Wachter4
Simon Xi3
Thomas Möller4
Knut P Biber5
Susanne M Kooistra1
Erik WGM Boddeke1
Bart JL Eggen1
1University of Groningen, University Medical Center Groningen
2University Medical Centre Utrecht, University Utrecht
3Foundational Neuroscience Center, AbbVie Inc.
4Neuroscience Discovery, AbbVie Deutschland GmbH and Co. KG
5Neuroscience Discovery, AbbVie Deutschland GmbH and Co. KG, Ludwigshafen, Germany.
Ami Day
To reference this project, please use the following link:
None
Downloaded and exported data is governed by the HCA Data Release Policy and licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0). For more information please see our Data Use Agreement.
Analysis Portals
NoneProject Label
SingleCellsAlzheimersSpecies
Homo sapiens
Sample Type
specimens
Anatomical Entity
brain
Organ Part
superior parietal cortex
Selected Cell Types
microglial cell
Disease Status (Specimen)
3 disease statuses
Disease Status (Donor)
3 disease statuses
Development Stage
human adult stage
Library Construction Method
3 library construction methods
Nucleic Acid Source
2 nucleic acid sources
Paired End
false, trueAnalysis Protocol
optimus_post_processing_v1.0.0, optimus_v4.2.3File Format
4 file formats
Cell Count Estimate
65.8kDonor Count
27bam2 file(s)fastq.gz398 file(s)loom3 file(s)tar1 file(s)