HCA Data Explorer

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

Updated September 30, 2021

Human kidney organoids hold promise for studying development, disease modelling and drug screening. However, the utility of stem cell-derived kidney tissues will depend on how faithfully these replicate normal fetal development at the level of cellular identity and complexity. Here, we present an integrated analysis of single cell datasets from human kidney organoids and human fetal kidney to assess similarities and differences between the component cell types.

Luke ZappiaMurdoch Childrens Research Institute
Luke Zappia (Experimental Scientist)1
1Murdoch Childrens Research Institute
Parisa Nejad
Tiana Pereira
Pranav Muthuraman

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/962bd805-eb89-4c54-bad2-008e497d1307

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Analysis Portals

None

Project Label

SC_analysis_kidney_organoids_fetal_kidney

Species

Homo sapiens

Sample Type

organoids

Anatomical Entity

skin of body

Organ Part

skin fibroblast

Selected Cell Types

Unspecified

Model Organ

kidney

Disease Status (Specimen)

normal

Disease Status (Donor)

normal

Development Stage

12th week post-fertilization human stage

Library Construction Method

10x 3' V2 sequencing

Nucleic Acid Source

single cell

Paired End

false

File Format

6 file formats

Cell Count Estimate

8.3k

Donor Count

1
bam13 file(s)csv2 file(s)fastq.gz26 file(s)loom14 file(s)mtx2 file(s)tsv4 file(s)