A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors
Updated July 22, 2022We perfomed single-cell RNA-sequnecing of around 10,000 cells from normal human liver tissue to construct a human liver cell atlas. We reveal previously unknown subtypes in different cell type compartments. Overall design: Single cells were isolated from human liver resection specimens and then sorted by FACS into 384 well plates in a unbiased way and on the basis of cell surface markers for distinct cell types. ScRNA-seq was done using the mCelSeq2 protocol.
A human liver cell atlas reveals heterogeneity and epithelial progenitors. (Official HCA Publication)
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Analysis Portals
NoneProject Label
LiverCellAtlasHeterogeneitySpecies
Sample Type
Anatomical Entity
Organ Part
Selected Cell Types
Model Organ
Disease Status (Specimen)
Disease Status (Donor)
Development Stage
Library Construction Method
Nucleic Acid Source
Paired End
falseAnalysis Protocol
analysis_protocol_normalization, analysis_protocol_quantificationFile Format
Cell Count Estimate
10.0kDonor Count
23