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A single cell atlas of the human proximal epididymis reveals cell-type specific functions and distinct roles for CFTR

Updated May 2, 2023

Spermatozoa released from the testis are unable to fertilize an egg without a coordinated process of maturation in the lumen of the epididymis. Relatively little is known about the molecular events that integrate this critical progression along the male genital ducts in man. Here, single cell RNA-sequencing was used to construct an atlas of the human proximal epididymis.

Ann HarrisCase Western Reserve University School of Medicine, and Case Comprehensive Cancer Centerann.harris@case.edu
Shih-Hsing Leir1
Shiyi Yin1
Jenny L Kerschner1
Wilmel Cosme1
Ann Harris1
1Case Western Reserve University School of Medicine, and Case Comprehensive Cancer Center
Ami Day

To reference this project, please use the following link:

https://explore.data.humancellatlas.org/projects/842605c7-375a-47c5-9e2c-a71c2c00fcad
None
INSDC Project Accessions:GEO Series Accessions:INSDC Study Accessions:

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Analysis Portals

None

Project Label

ProximalEpididymisCFTR

Species

Homo sapiens

Sample Type

specimens

Anatomical Entity

testis

Organ Part

epididymis

Selected Cell Types

Unspecified

Disease Status (Specimen)

normal

Disease Status (Donor)

testicular cancer

Development Stage

human adult stage

Library Construction Method

10X 3' v2 sequencing

Nucleic Acid Source

single cell

Paired End

false

File Format

6 file formats

Cell Count Estimate

7.5k

Donor Count

3
bam3 file(s)csv1 file(s)fastq.gz6 file(s)loom4 file(s)tar1 file(s)xlsx1 file(s)