Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
Updated August 30, 2022The authors captured 301 single cells from 11 populations using microfluidics and analyzing single-cell transcriptomes across downsampled sequencing depths. They demonstrate that shallow single-cell mRNA sequencing (∼50,000 reads per cell) is sufficient for unbiased cell-type classification and biomarker identification in the developing cortex.
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Analysis Portals
NoneProject Label
DevelopingCerebralCortexSpecies
Sample Type
Anatomical Entity
Organ Part
Selected Cell Types
Model Organ
Disease Status (Specimen)
Disease Status (Donor)
Development Stage
Library Construction Method
Nucleic Acid Source
Paired End
trueAnalysis Protocol
analysis_protocolFile Format
Cell Count Estimate
301Donor Count
43